NETosis as Source of Autoantigens in Rheumatoid Arthritis
نویسندگان
چکیده
منابع مشابه
NETosis as Source of Autoantigens in Rheumatoid Arthritis
In neutrophils (but also in eosinophils and in mast cells), different inflammatory stimuli induce histone deimination, chromatin decondensation, and NET formation. These web-like structures that trap and kill microbes contain DNA, cationic granule proteins, and antimicrobial peptides, but the most abundant proteins are core histones. Histones contained in NETs have been deiminated, and arginine...
متن کاملNETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neutrophils isolated from patients with various autoimmune diseases display enhanced neutrophil extracellular trap (NET) formation, a phenomenon that exposes autoantigens in the context of immunos...
متن کاملControl of Rheumatoid Arthritis in Developing Countries
بیماری روماتیسم قلبی یکی از شایعترین علل مرگ و میر ناشی از بیماریهای قلبی و عروقی در کشورهای در حال توسعه می باشد. براساس بررسیهای انجام شده، میزان شیوع بیماری در جامعه و مدارس از ۱ الی ۲۲ در هر هزار نفر کودک می باشد. تخمین زده میشود که تعداد مبتلایان به بیماریهای مزمن روماتیسم قلبی در کشورهای در حال توسعه ۳۰ میلیون و در کشورهای صنعتی ۱ / ۵ میلیون باشد. بسیاری از موارد مرگ و میر ناشی از این بیم...
متن کاملComparing bone mineral density in rheumatoid arthritis and psoriatic arthritis
Background: Changes in patients’ bone mineral density (BMD) is one of the problems in patients with rheumatoid arthritis, which can be due to the use of corticosteroid drugs to reduce patients' symptoms or due to the aging process in patients. In this study, we decided to compare BMD in patients with psoriatic arthritis and rheumatoid arthritis. Methods: This study as a cross-sectional descrip...
متن کاملANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODI ES IN RHEUMATOID ARTHRITIS
Antineutrophil cytoplasmic autoantibodies (ANCA) were detected in patients with autoimmune and vascular diseases such as Wegener's granulomatosis, polyarteritis nodosa and systemic lupus erythematosus. Indirect immunofluorescence (IIF) technique was employed to detect these autoantibodies. By this method, two general patterns of ANCA were seen: a cytoplasmic (cANCA) and a perinuclear form ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2016
ISSN: 1664-3224
DOI: 10.3389/fimmu.2016.00485